In search of molecular mechanisms underlying sex differences in cardiac arrythmia
9 May 2022 at 16:00:00
In general, women are at increased risk of suffering from cardiac arrhythmias compared to men. This has been suggested to be due to distinct hormone profiles of steroid sex hormones like estrogen, progesterone and testosterone between women and men, which contributes to differences in cardiovascular electrophysiology between the sexes. However, there are limited mechanistic insights into how sex hormones modulate the activity of many of the proteins critical for tuning cardiac function. In this project, we aim to understand how the female steroid sex hormone modulates one of the key cardiac ion channels.
Sara has gotten her PhD in Neurobiology at Linköping University and is now an Associate Professor with her own lab group. She was awarded the Eric K Fernström award for young scientists last year. Sara’s aim is to try to understand how mutated ion channels can cause disease and how to develop new treatment strategies.